ESC4000A-E12 2U Server

Key Applications

  • Streaming Media
  • Cloud Computing
  • Virtualized & VDI Application
  • Enterprise & HPC Application

Key Features

  • Powerful performance: Powered by AMD EPYC 9004 processors with 96 Zen 4 cores, 12-channel, up to 4800 MHz DDR5 and support for a maximum TDP of up to 400 watts per socket
  • AI and HPC workloads ready: Up to four dual-slot active or passive GPUs, NVIDIA NVLink® bridge, and NVIDIA Bluefield DPU support to enable performance scaling
  • Power-efficient system design: Independent CPU and GPU airflow tunnels for thermal optimization and support for up to two 2600W Titanium redundant power supplies for uninterrupted operation
  • Comprehensive cooling solutions: Designed for both liquid cooling and enhanced air cooling based on CPU TDP for versatile workloads
  • Scale-up storage and expansion design: A total of six bays in combination of Tri-Mode NVMe/SATA/SAS drives on the front panel and eight PCIe 5.0 slots for higher bandwidth and system upgrade
  • Flexible networking module design: Optional OCP 3.0 module with PCIe 5.0 slot in rear panel for faster connectivity
  • Enhanced IT-infrastructure management: ASUS ASMB11-iKVM remote control with ASPEED AST2600, ASUS Control Center IT management software and hardware-level Root-of-Trust solution


Product Specifications

Processor Support
1 x Socket SP5 (LGA 6096)
Core Logic
CPU AMD EPYC™ 9004 series (up to 400W)
System Memory
Total slots 12 (12-channel per CPU, 12 DIMM per CPU)
Capacity Maximum up to 3TB per CPU socket
Memory Type DDR5 4800/4400 RDIMM/ 3DS RDIMM
*Please refer to for latest momory AVL update
Memory Size 64GB, 32GB, 16GB RDIMM
256GB, 128GB 3DS RDIMM
*Refer to for more information
Disk Controller
SATA Controller 6 x SATA 6Gb/s ports
SAS Controller Optional kits:
ASUS PIKE II 3008 8-port SAS 12Gb/s HBA card
ASUS PIKE II 3108 8-port SAS HW 12Gb/s RAID card
Broadcom MegaRAID 9540-8i
Broadcom MegaRAID 9560-16i
LAN 2 x Gigabit LAN ports (Intel I350 Controller)
1 x Management Port
VGA Aspeed AST2600 64MB
I/O Ports
Front I/0 Ports 4 x USB 3.2 Gen1 ports
Rear I/O Ports 2 x USB 3.2 Gen1 ports
2 x Gigabit LAN ports (RJ45)
1 x MAnagement port (RJ45)
1 x VGA port
OS Support
Windows Server
RedHat® Enterprise Linux
SuSE® Linux Enterprise Server

*Please find the latest OS support from
Software ASUS Control Center (Classic)
Out of Band Remote Management On-Board ASMB11-iKVM
Expansion Slots
Total PCI/PCI-X/PCI-E/PIKE Slots 12
Slot Type Rear:
-4 x PCIe x16 slots (Gen5 x16 link, FH, FL) for dual-slot GPU cards or
8 x PCIe x16 slots (Gen5 x8 link, FH,FL) for single-slot GPU cards

-1 x PCIe x16 slots (Gen5 x16 link, FH, HL)
-1 x PCIe x16 slot (Gen5 x16/x8 link, FH, HL) or OCP socket option
-1 x PCIe x8 slot (Gen5 x0/x8 link, LP, HL)

Front: 1 x PCIe x8 slot (Gen5 x8 link, LP, HL) Only for SKU1
Storage Bays
I = internal
A or S will be hot-swappable
2 x 2.5” & 4 x 3.5“ Hot-swap Storage Bays

2 x 2.5” SATA/SAS*/NVMe +
2 x 3.5” SATA/SAS*/NVMe + 2 x 3.5” SATA/SAS*

SKU2: Build to order
2 x 2.5” SATA/SAS*/NVMe +
4 x 3.5” SATA/SAS*/NVMe (Occupy 1 x PCIe x8 link )

*SAS support required a HBA/RAID card.

**For SKU1 additional 2 x NVMe support required a RAID card.
Dimensions and Weight
Dimensions 800mm x 439.5mm x 88.9mm (2U)
845.45mm x 439.5mm x 88.9mm (2U) for immersion cooling
Net Weight Kg
(CPU, DRAM & HDD not included)
24 kg
Gross Weight Kg
(CPU, DRAM & HDD not included, Packing include)
34.8 kg
Power Supply
1+1 Redundant 2600W 80 PLUS Titanium CRPS-R Power Supply
Operating Environment
Environmental Spec. Operating Temperature:
10°C ~ 35°C
Non-operating Temperature:
-40°C to 70°C
Non-operating Humidity:
20% ~ 90% (non-condensing)

Speak with an expert to learn more.